Sufficient tissue perfusion is an essential condition for wound healing. Gaining insight into local tissue perfusion is therefore essential for the diagnosis, prognosis and treatment of patients with perfusion-related diseases.
Quantified analysis of local tissue perfusion, using two-dimensional perfusion angiography, laser speckle contrast imaging and fluorescence angiography, has the potential to gain more insight into the optimal treatment for the individual patient and thus improve the cost-effectiveness of treatment and reduce social costs.
This project will develop software and improve and validate imaging systems to enable quantified tissue perfusion with the imaging techniques: two-dimensional perfusion angiography, laser speckle contrast imaging, fluorescent angiography and photoacoustics.